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吉林台

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    吉林台,男,蒙古族,19681113日生,内蒙古赤峰市人。基础兽医学系兽医病理学教研室,2017年引进人才,主要承担家畜病理学课程。主要研究方向为传染病病理及人畜共患病病原体分子生物学研究。20073月在日本岐阜大学联合兽医学研究科获得兽医学博士学位之后,先后在日本国的带広畜产大学,国立感染症研究所,自治医科大学等大学和研究机构从事科学研究工作,作为主要成员参与了日本国内重大项目及国际合作项目。目前仍和日方大学和研究机构保持良好的科研合作和学术交流关系。

教育背景

1986.9-1991.7     原内蒙古农牧学院兽医系 兽医专业 获得学士学位

1991.9-1994.7     原内蒙古农牧学院兽医系 兽医病理学专业 获得硕士学位

2002.4-2007.3     日本岐阜大学大学院 獣医临床病理学学専攻 获得博士学位

工作经历

1994.7-2001.9 内蒙古农业大学 医病理学教研室     助教讲师

2007.4-2008.3  日本广畜大学 学研究室 博士后研究

2008.4-2009.3 日本国立感染症研究所 病毒学第一部    任期制研究

2009.4-2017.4  日本自治医科大学及日本特殊免疫研究所 研究

2017.5-    内蒙古农业大学医学院 引进人才

科研项目:

在日本期间作为主要成员参与的项目有下:

1.             关于中国新疆地区家畜住血细胞原虫感染症的分子流行病学调查,日本学术振兴会研究项目(2005,4-2006,3), 承担血清抗体检测及病原体基因检测。

2.             通过调查日本立克氏体感染症状况及早期诊断体系的建立而构建早期预警系统, 日本厚生劳动省科学研究项目(2006,42008,3), 主要承担病原体基因检索及特异性诊断方法的开发。

3.             解明立克氏体感染对于畜禽的疾病发生与生产性能的影响以及其特异性诊断方法的研究, 日本学術振興会研究项目(2006,42008,3), 进行血清抗体检测及病原体基因检索,特殊诊断制剂的研发。

4.             通过调查日本国内的立克氏体感染症实况及早期诊断体系的建立而构建早期警报系统, 日本厚生劳动省科学研究项目(2008,42009,3), 承担血清抗体及病原体基因检测,快速诊断方法的开发。

5.             关于经口感染型病毒性肝炎(甲肝及戊肝)的防止, 病态解析, 基因多样性及治疗的研究,,日本厚生劳动省科学研究项目(2009,42012,3), 担任动物戊肝病毒的分离鉴定及细胞培养系统的构建。

6.             关于经口感染型病毒性肝炎(甲肝及戊肝)的防止,病态解析,基因多样性及治疗的研究。日本厚生劳动省科学研究项目(2012,42017,3), 运用细胞培养系统进行了戊肝病毒在细胞内的复制及释放到细胞外的机制的研究,戊肝病毒抗病毒药物的筛选及药物作用机制的研究。

发表论文

1.             Jirintai S, Tanggis B, Takahashi M, Kobayashi T, Nagashima S, Nishizawa T, Okamoto H: Rat hepatitis E virus from wild rats (Rattus rattus) can propagate efficiently in human hepatoma cell lines. Virus Res. 185:92-102, 2014

2.             Jirintai S, Jinshan, Tanggis, Manglai D, Mulyanto, Takahashi M, Nagashima S, Kobayashi T, Nishizawa T, Okamoto H: Molecular analysis of hepatitis E virus from farm rabbits in Inner Mongolia, China and its successful propagation in A549 and PLC/PRF/5 cells. Virus Res. 170 (1-2):126-37, 2012.

3.             Jilintai, Seino N, Hayakawa D, Suzuki M, Hata H, Kondo S, Matsumoto K, Yokoyama N, Inokuma H: Molecular survey for Anaplasma bovis and Anaplasma phagocytophilum infection in cattle in a pastureland where sika deer appear in Hokkaido, Japan. Jpn J Infect Dis. 62:73-75, 2009.

4.             Jilintai, Seino N, Matsumoto K, Hayakawa D, Suzuki M, Hata H, Kondo S, Yokoyama N, Inokuma H: Serological and molecular survey of rickettsial infection in cattle and sika deer in a pastureland in Hidaka District, Hokkaido, Japan. Jpn J Infect Dis. 61:315-317, 2008.

5.             Jilintai, Hashiyama S, Gonda Y, Ishikawa H, Sato M, Miyahara K: Radiographic evaluation of caudal vena cava size as a useful parameter for the diagnosis of heart disease in dairy cattle. J Vet Med Sci. 68:995-998, 2006.

6.             Jinshan, Jirintai, Manglai D, Takahashi M, Nagashima S, Okamoto H: Molecular and serological survey of hepatitis E virus infection among domestic pigs in Inner Mongolia, China. Arch Virol. 155:1217-1226, 2010.

7.             Tanggis, Kobayashi T, Takahashi M, Jirintai S, Nishizawa T, Nagashima S, Nishiyama T, Kunita S, Hayama E, Tanaka T, Mulyanto, Okamoto H. An analysis of two open reading frames (ORF3 and ORF4) of rat hepatitis E virus genome using its infectious cDNA clones with mutations in ORF3 or ORF4. Virus Res. 2018 Apr 2; 249:16-30.

8.             Primadharsini PP, Mulyanto, Wibawa IDN, Anggoro J, Nishizawa T, Takahashi M, Jirintai S, Okamoto H. The identification and characterization of novel rat hepatitis E virus strains in Bali and Sumbawa, Indonesia. Arch Virol. 2018 May;163(5):1345-1349

9.             Primadharsini PP, Miyake M, Kunita S, Nishizawa T, Takahashi M, Nagashima S, Tanggis, Ohnishi H, Kobayashi T, Nishiyama T, Jirintai S, Okamoto H. Full-length genome of a novel genotype 3 hepatitis E virus strain obtained from domestic pigs in Japan. Virus Res. 2017 Aug 15; 240:147-153.

10.         Tsatsralt-Od B, Primadharsini PP, Nishizawa T, Ohnishi H, Nagashima S, Takahashi M, Jirintai S, Nyamkhuu D, Okamoto H. Distinct changing profiles of hepatitis A and E virus infection among patients with acute hepatitis in Mongolia: The first report of the full genome sequence of a novel genotype 1 hepatitis E virus strain. J Med Virol. 2018 Jan;90(1):84-92.

11.         Takahashi M, Kobayashi T, Tanggis, Jirintai S, Mulyanto, Nagashima S, Nishizawa T, Kunita S, Okamoto H. Production of monoclonal antibodies against the ORF3 protein of rat hepatitis E virus (HEV) and demonstration of the incorporation of the ORF3 protein into enveloped rat HEV particles. Arch Virol. 161(12):3391-3404, 2016.

12.         Nagashima S, Kobayashi T, Tanaka T, Tanggis, Jirintai S, Takahashi M, Nishizawa T, Okamoto H. Analysis of adaptive mutations selected during the consecutive passages of hepatitis E virus produced from an infectious cDNA clone. Virus Res. 223:170-180,2016.

13.         Kobayashi T, Takahashi M, Tanggis, Mulyanto, Jirintai S, Nagashima S, Nishizawa T, Okamoto H.Characterization and epitope mapping of monoclonal antibodies raised against rat hepatitis E virus capsid protein: An evaluation of their neutralizing activity in a cell culture system. J Virol Methods. 233:78-88,2016.

14.         Nagashima S, Jirintai S, Takahashi M, Kobayashi T, Tanggis, Tom Kouki, Takashi Yashiro, Nishizawa T, Okamoto H: Hepatitis E virus egress depends on the exosomal pathway, with secretory exosomes derived from multivesicular bodies. J Gen Virol. 95: 2166-2175, 2014.

15.         Takahashi M, Nishizawa T, Nagashima S, Jirintai S, Kawakami M, Sonoda Y, Suzuki T, Yamamoto S, Shigemoto K, Ashida K, Sato Y, Okamoto H: Molecular characterization of a novel hepatitis E virus (HEV) strain obtained from a wild boar in Japan that is highly divergent from the previously recognized HEV strains. Virus Res. 180:59-69, 2014.

16.         Mulyanto, Jodeph BS, I Gusti ASA, Khalid, Takahashi M, Ohnishi H, Jirintai S, Nagashima S, Nishizawa T, Okamoto H: Marked genomic heterogeneity of rat hepatitis E virus strains in Indonesia demonstrated on a full-length genome analysis. Virus Res. 179:102-112, 2014.

17.         Nagashima S, Takahashi M, Jirintai S, Tanggis B, Kobayashi T, Nishizawa T, Okamoto H: The membrane on the surface of hepatitis E virus particles is derived from the intracellular membrane and contains trans-Golgi network protein 2. Arch Virol. 159 (5):979-991, 2014.

18.         Mulyanto, Depamede SN, Sriasih M, Takahashi M, Nagashima S, Jirintai S, Nishizawa T, Okamoto H: Frequent detection and characterization of hepatitis E virus variants in wild rats (Rattus rattus) in Indonesia. Arch Virol. 158(1):87-96, 2012.

19.         Takahashi H, Tanaka T, Jirintai S, Nagashima S, Takahashi M, Nishizawa T, Mizuo H, Yazaki Y, Okamoto H: A549 and PLC/PRF/5 cells can support the efficient propagation of swine and wild boar hepatitis E virus (HEV) strains: demonstration of HEV infectivity of porcine liver sold as food. Arch Virol. 157:235-246, 2012.

20.         Mulyanto, Pancawardani P, Depamede SN, Wahyono A, Jirintai S, Nagashima S, Takahashi M, Nishizawa T, Okamoto H: Identification of four novel subgenotypes (C13-C16) and two inter-genotypic recombinants (C12/G and C13/B3) of hepatitis B virus in Papua Province, Indonesia. Virus Res. 163:129-140, 2012.

21.         Nagashima S, Takahashi M, Jirintai S, Tanaka T, Nishizawa T, Yasuda J, Okamoto H: Tumour susceptibility gene 101 and the vacuolar protein sorting pathway are required for the release of hepatitis E virions. J Gen Virol. 92:2838-2848, 2011.

22.         Nagashima S, Takahashi M, Jirintai, Tanaka T, Yamada K, Nishizawa T, Okamoto H: A PSAP motif in the ORF3 protein of hepatitis E virus is necessary for virion release from infected cells. J Gen Virol. 92:269-278, 2011.

23.         Mulyanto, Depamede SN, Wahyono A, Jirintai, Nagashima S, Takahashi M, Okamoto H: Analysis of the Full-Length Genomes of Novel Hepatitis B Virus Subgenotypes C11 and C12 in Papua, Indonesia. J Gen Virol. 83:54-64, 2011.

24.         Takahashi M, Nishizawa T, Sato H, Sato Y, Jirintai, Nagashima S, Okamoto H: Analysis of the full-length genome of a hepatitis E virus isolate obtained from a wild boar in Japan that is classifiable into a novel genotype. J Gen Virol. 92:902-908, 2011.

25.         Yokoyama K, Takahashi M, Nishizawa T, Nagashima S, Jirintai S, Yotsumoto S, Okamoto H, Momoi MY: Identification and characterization of a natural inter-genotypic (2b/1b) recombinant hepatitis C virus in Japan. Arch Virol. 156:1591-1601, 2011.

26.         Sato Y, Sato H, Naka K, Furuya S, Tsukiji H, Kitagawa K, Sonoda Y, Usui T, Sakamoto H, Yoshino S, Shimizu Y, Takahashi M, Nagashima S, Jirintai, Nishizawa T, Okamoto H: A nationwide survey of hepatitis E virus (HEV) infection in wild boars in Japan: identification of boar HEV strains of genotypes 3 and 4 and unrecognized genotypes. Arch Virol. 156:1345-1358, 2011.

27.         Takahashi M, Tanaka T, Takahashi H, Hoshino Y, Nagashima S, Jirintai, Mizuo H, Yazaki Y, Takagi T, Azuma M, Kusano E, Isoda N, Sugano K, Okamoto H: Hepatitis E Virus (HEV) Strains in Serum Samples Can Replicate Efficiently in Cultured Cells Despite the Coexistence of HEV Antibodies: Characterization of HEV Virions in Blood Circulation. J Clin Microbiol. 48:1112-1125, 2010.

28.         Mulyanto, Depamede SN, Surayah K, Tjahyono AAH, Jirintai, Nagashima S, Takahashi M, Okamoto H: Identification and characterization of novel hepatitis B virus subgenotype C10 in Nusa Tenggara, Indonesia. Arch Virol. 155:705-715, 2010.

29.         Ichiyama K, Yamada K, Tanaka T, Nagashima S, Jirintai, Takahashi M, Okamoto H: Determination of the 5'-terminal sequence of subgenomic RNA of hepatitis E virus strains in cultured cells. Arch Virol. 154:1945-1951, 2009.

30.         Chahan B, Jian Z, Jilintai, Miyahara K, Tanabe S, Xuan X, Sato Y, Moritomo T, Nogami S, Mikami T, Maruyama S, Inokuma H: Detection of DNA closely related to 'Candidatus Rickettsia principis' in Haemaphysalis danieli recovered from cattle in Xinjiang Uygur Autonomous Region Area, China. Vet Parasitol. 144:184-187, 2007.

31.         Inokuma H, Ohashi M, Jilintai, Tanabe S, Miyahara K: Prevalence of tick-borne Rickettsia and Ehrlichia in Ixodes persulcatus and Ixodes ovatus in Tokachi district, Eastern Hokkaido, Japan. J Vet Med Sci. 69:661-664, 2007.

32.         Tabuchi M, Jilintai, Sakata Y, Miyazaki N, Inokuma H: Serological survey of Rickettsia japonica infection in dogs and cats in Japan. Clin Vaccine Immunol. 14:1526-1528, 2007.

33.         猪熊壽,吉林台,下田 崇,富樫義彦,古林与志安,古岡秀文,佐藤基佳,石井三都夫: 右心房内に血栓を認めた後大静脈血栓症の育成牛の1症例.日本獣医師会雑誌.62(5)376-378, 2009.

34.         山川和宏,杉粼義一,吉林台,古林与志安,古岡秀文,佐々木直樹,石井三都夫,猪熊 壽: 片側性胸水と血様心嚢水貯留を認めた乳牛の1症例.日本獣医師会雑誌. 62(1):49-51, 2008.

35.         青木大介,滄木孝弘,下田崇,富樫義彦,風間武彦,吉林台,宮原和郎,古林与志安,古岡秀文,松井高峯,佐々木直樹,石井三都夫,猪熊壽: 分娩後5カ月以上経過して症状を発現した心室中隔欠損(VSD)の乳牛の2. 北海道獣医師会雑誌. 52 (6): 219-221, 2008.

36.         赵振华, 李向宇, 关平原, 日穆德玛, 赵心力, 顾玉芳, 吉仁泰, 王凤龙, 马学恩, 吴钟灵, 成子强. 禽脑脊髓炎油乳剂灭活疫苗的研究. 中国预防兽医学报, 22(S1), 160-162, 2000.

37.         赵振华,顾玉芳,李润清,赵心力, 郝俊峰, 吉林台, 王凤龙, 马学恩. 禽脑脊髓炎发病机理的研究. 中国畜禽传染病. 82(3): 42-48, 1995.

38.         赵振华,林曦,禹旺盛,郝先谱,顾玉芳,马学恩,李润清,赵心力,王凤龙,吉仁泰.禽脑脊髓炎的病理学研究. 中国兽医杂志. 21(3):5-7, 1995.

39.         赵心力,郭金贵, 马学恩,李润清, 吉仁泰, 赵振华, 斯琴,那日苏. 禽脑脊髓炎琼脂扩散沉淀抗原制备与应用的研究. 中国畜禽传染病. 中国兽医科技. 25(2): 6-8, 1995.

40.         赵心力,赵振华,马学恩,吉仁泰,顾玉芳,王凤龙,李润清. 禽脑脊髓炎病毒的分离与鉴定. 中国畜禽传染病. 81(2):3-7, 1995.

联系方式:jirintais@imau.edu.cn;  jirintai@hotmail.com


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