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刘博

添加时间:2016-09-07 09:20:19  浏览次数:[]

 

刘博,男,汉族,19855月生,中共党员,副教授,黑龙江省哈尔滨市人,主要研究方向为奶牛乳腺炎及子宫内膜炎诊断防治。  

2008年毕业于东北林业大学野生动物资源学院动物医学专业,获得学士学位;2013年硕博连读毕业于吉林大学动物医学学院临床兽医学专业,获得博士学位;2013年通过高层次人才引进计划(第五层次A类)进入内蒙古农业大学兽医学院临床兽医学内科教研室工作。  

主持及参与课题情况:  

[1] 国家自然科学基金项目“PGE2PGF对奶牛子宫内膜上皮细胞TLR2TLR4RP105参与的信号转导通路激活的调控”,项目号315607142016.01-2019.1249.2万元,主持;  

[2] 内蒙古自治区自然科学基金项目“PGFPGE2在奶牛子宫内膜上皮细胞中对TLRs介导的天然免疫的调控”,项目号2014BS03232014.01-2016.0123万元,主持;  

[3] 内蒙古农业大学优秀青年科学基金项目“PGFPGE2在奶牛乳腺上皮细胞TLRs介导的天然免疫中的调控作用”,项目号2014XYQ-32014.10-1017.1015万元,主持;  

[4] 内蒙古农业大学引进人才科研启动基金“PGFPGE2对金葡菌在奶牛乳腺上皮细胞中的存活和细胞天然免疫应答的影响”,项目号YJ2014-32015.01-2017.1210万元,主持;  

[5] 国家自然科学基金面上项目“奶牛乳腺黏膜抗感染免疫机制研究”,31万元,项目号309722252010.01-2012.12,参加。  

近年文章发表情况:  

[1] RP105 involved in activation of mouse macrophages via TLR2 and TLR4 signaling. Bo Liu, Naisheng Zhang, Zhicheng Liu, Yunhe Fu, Shuang Feng, Shan Wang, Yongguo Cao, Depeng Li, Dejie Liang, Fengyang Li, Xiaojing Song, Zhengtao Yang*. Molecular and Cellular Biochemistry. 2013 Jun; 378(1-2):183-93.(第一作者)  

[2] Involvement of RP105 and Toll-like receptors in the activation of mouse peritoneal macrophages by Staphylococcus aureus. Bo Liu, Yunhe Fu, Shuang Feng, Xichen Zhang, Zhicheng Liu, Yongguo Cao, Depeng Li, Dejie Liang, Fengyang Li, Naisheng Zhang, Zhengtao Yang*. Scand J Immunol. 2013 Jul;78(1):8-16.(第一作者)  

[3] The effect of magnolol on the Toll-like receptor 4/nuclear factor kappa B signaling pathway in lipopolysaccharide-induced acute lung injury in mice. Yunhe F, Bo L, Xiaosheng F, Fengyang L, Dejie L, Zhicheng L, Depeng L, Yongguo C, Xichen Z, Naisheng Z*, Zhengtao Y*. Eur J Pharmacol. 2012 Aug 15;689(1-3):255-61.(并列第一作者)  

[4] Geniposide, from Gardenia jasminoides Ellis, inhibits the inflammatory response in the primary mouse macrophages and mouse models. Fu Y, Liu B, Liu J, Liu Z, Liang D, Li F, Li D, Cao Y, Zhang X, Zhang N*, Yang Z*. Int Immunopharmacol. 2012 Dec;14(4):792-8.(并列第一作者)  

[5] Prostanoid receptors EP2, EP4, and FP are regulated by estradiol in bovine oviductal smooth muscle. Huang N, Liu B, Dong Z, et al. J. Prostaglandins Other Lipid Mediat. 2015 Sep;121(Pt B):170-5.(并列第一作者)  

[6] Magnolol inhibits lipopolysaccharide-induced inflammatory response by interfering with TLR4 mediated NF-κB and MAPKs signaling pathways. Fu Y, Liu B, Zhang N, Liu Z, Liang D, Li F, Cao Y, Feng X, Zhang X*, Yang Z*. J Ethnopharmacol. 2013 Jan 9;145(1):193-9.    

[7] Lipopolysaccharide increases Toll-like receptor 4 and downstream Toll-like receptor signaling molecules expression in bovine endometrial epithelial cells. Fu Y, Liu B, Feng X, Liu Z, Liang D, Li F, Li D, Cao Y, Feng S, Zhang X, Zhang N, Yang Z*. Vet Immunol Immunopathol. 2013 Jan 15;151(1-2):20-7.    

[8] Stevioside suppressed inflammatory cytokine secretion by downregulation of NF-κB and MAPK signaling pathways in LPS-stimulated RAW264.7 cells. Fengyang L, Yunhe F, Bo L, Zhicheng L, Depeng L, Dejie L, Wen Z, Yongguo C, Naisheng Z, Xichen Z*, Zhengtao Y*. Inflammation. 2012 Oct;35(5):1669-75.    

[9] Farrerol regulates antimicrobial peptide expression and reduces Staphylococcus aureus internalization into bovine mammary epithelial cells. Yang Z, Fu Y, Liu B, Zhou E, Liu Z, Song X, Li D, Zhang N*. Microb Pathog. 2013 Dec;65:1-6.    

[10] Kinetic effect of oestrogen on secretion of prostaglandins E2 and F2? in bovine oviduct epithelial cells.  

Dong Z, Zhang N, Mao W, Liu B, Huang N, Li P, Li C, Cao J. Reprod Fertil Dev. 2015 Aug 27. doi: 10.1071/RD15246. [Epub ahead of print]    

[11] Salidroside attenuates inflammatory responses by suppressing nuclear factor-κB and mitogen activated protein kinases activation in lipopolysaccharide-induced mastitis in mice. Li D, Fu Y, Zhang W, Su G, Liu B, Guo M, Li F, Liang D, Liu Z, Zhang X, Cao Y, Zhang N, Yang Z*. Inflamm Res. 2013 Jan;62(1):9-15.    

[12] Staphylococcus aureus and Escherichia coli elicit different innate immune responses from bovine mammary epithelial cells. Fu Y, Zhou E, Liu Z, Li F, Liang D, Liu B, Song X, Zhao F, Fen X, Li D, Cao Y, Zhang X, Zhang N, Yang Z*. Vet Immunol Immunopathol. 2013 Oct 1;155(4):245-52.    

[13] Emodin ameliorates lipopolysaccharide-induced mastitis in mice by inhibiting activation of NF-κB and MAPKs signal pathways. Li D, Zhang N, Cao Y, Zhang W, Su G, Sun Y, Liu Z, Li F, Liang D, Liu B, Guo M, Fu Y, Zhang X, Yang Z*. Eur J Pharmacol. 2013 Apr 5;705(1-3):79-85.    

 

联系方式:liubo8510@live.cnliubo8510@imau.edu.cn

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