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刘博

添加时间:2018-03-07 15:44:41  浏览次数:[]

 

刘博,男,汉族,黑龙江省哈尔滨市人,1985年5月生,中共党员,副教授,硕士生导师,内蒙古自治区高等学校青年科技英才支持计划入选者,主要研究方向为奶牛乳腺炎及子宫内膜炎诊断防治。

教育及工作经历
2008年毕业于东北林业大学野生动物资源学院动物医学专业,获得学士学位;
2013年硕博连读毕业于吉林大学动物医学学院临床兽医学专业,获得博士学位;
2013年通过高层次人才引进计划(第五层次A类)进入内蒙古农业大学兽医学院临床兽医学内科教研室工作。

主持及参与课题情况
[1] 国家自然科学基金项目,PGE2和PGF2α对奶牛子宫内膜上皮细胞TLR2、TLR4及RP105参与的信号转导通路激活的调控,项目号31560714,2016.01-2019.12,49.2万元,主持;
[2]内蒙古自治区高等学校青年科技英才支持计划,项目号NJYT-18-B03,2018.01-2019.12,20万元,主持;
[3] 内蒙古自治区自然科学基金项目,PGF2α和PGE2在奶牛子宫内膜上皮细胞中对TLRs介导的天然免疫的调控,项目号2014BS0323,2014.01-2016.12,3万元,主持;
[4] 内蒙古农业大学优秀青年科学基金培养项目,金黄色葡萄球菌脂蛋白在TLRs及NLRP3炎性复合体介导的小鼠巨噬细胞激活中的作用研究,项目号2017XYQ-2,2018.01-2020.12,29万元,主持;
[5] 内蒙古农业大学优秀青年科学基金项目,PGF2α和PGE2在奶牛乳腺上皮细胞TLRs介导的天然免疫中的调控作用,项目号2014XYQ-3,2014.10-2017.10,15万元,主持;
[6] 内蒙古农业大学引进人才科研启动基金,PGF2α和PGE2对金葡菌在奶牛乳腺上皮细胞中的存活和细胞天然免疫应答的影响,项目号YJ2014-3,2015.01-2017.12,10万元,主持;
[7] 国家自然科学基金面上项目,奶牛乳腺黏膜抗感染免疫机制研究,31万元,项目号30972225,2010.01-2012.12,参加。

SCI论文发表情况
第一及通讯作者署名SCI论文:
[1] PGE2 downregulates LPS-induced inflammatory responses via the TLR4-NF-κB signaling pathway in bovine endometrial epithelial cells.Shen Y#, Liu B#,*, Mao W, Gao R, Feng S, Qian Y, Wu J, Zhang S, Gao L, Fu C, Li Q, Deng Y, Cao J*.Prostaglandins LeukotEssent Fatty Acids. 2018 Feb;129:25-31.ReprodDomest Anim. 2018 Feb;53(1):143-151.
[2] Concentration effect of prostaglandin E2 on the growth factor expression and cell proliferation in bovine endometrial explants and their kinetic characteristics.Zhang S#, Mao W#, Li Q, Gao R, Zhang Y, Gao L, Fu C, Wu J, Deng Y, Shen Y, Li T, Liu B*, Cao J*.ReprodDomest Anim. 2018 Feb;53(1):143-151.
[3] PTGER2 activation induces PTGS-2 and growth factor gene expression in endometrial epithelial cells of cattle.Gao L#, Liu B#, Mao W, Gao R, Zhang S, Duritahala, Fu C, Shen Y, Zhang Y, Zhang N, Wu J, Deng Y, Wu X, Cao J*.AnimReprod Sci. 2017 Dec;187:54-63.
[4] Prostaglandin F2α-PTGFR signalling activation, growth factor expression and cell proliferation in bovine endometrial explants.Zhang S#, Liu B#, Gao L, Mao W, Fu C, Duritahala D, Zhang N, Zhang Y, Shen Y, Cao J*.ReprodFertil Dev. 2017 Oct;29(11):2195-2205.
[5] The effect of prostaglandin E2 receptor (PTGER2) activation on growth factor expression and cell proliferation in bovine endometrial explants.Zhang S#, Liu B#, Mao W, Li Q, Fu C, Zhang N, Zhang Y, Gao L, Shen Y, Cao J*.Prostaglandins LeukotEssent Fatty Acids. 2017 Jul;122:16-23.
[6] Prostanoid receptors EP2, EP4, and FP are regulated by estradiol in bovine oviductal smooth muscle.Huang N#, Liu B#, Dong Z, Mao W, Zhang N, Li C, Cao J*.Prostaglandins Other Lipid Mediat. 2015 Sep;121(Pt B):170-5.
[7] Involvement of RP105 and Toll-like receptors in the activation of mouse peritoneal macrophages by Staphylococcus aureus. Bo Liu, Yunhe Fu, Shuang Feng, Xichen Zhang, Zhicheng Liu, Yongguo Cao, Depeng Li, Dejie Liang, Fengyang Li, Naisheng Zhang, Zhengtao Yang*. Scand J Immunol. 2013 Jul;78(1):8-16.
[8] RP105 involved in activation of mouse macrophages via TLR2 and TLR4 signaling. Bo Liu, Naisheng Zhang, Zhicheng Liu, Yunhe Fu, Shuang Feng, Shan Wang, Yongguo Cao, Depeng Li, Dejie Liang, Fengyang Li, Xiaojing Song, Zhengtao Yang*. Molecular and Cellular Biochemistry. 2013 Jun; 378(1-2):183-93.
[9] Geniposide, from Gardenia jasminoides Ellis, inhibits the inflammatory response in the primary mouse macrophages and mouse models. Fu Y#, Liu B#, Liu J, Liu Z, Liang D, Li F, Li D, Cao Y, Zhang X, Zhang N*, Yang Z*. IntImmunopharmacol. 2012 Dec;14(4):792-8.
[10] The effect of magnolol on the Toll-like receptor 4/nuclear factor kappa B signaling pathway in lipopolysaccharide-induced acute lung injury in mice. Yunhe F#, Bo L#, Xiaosheng F, Fengyang L, Dejie L, Zhicheng L, Depeng L, Yongguo C, Xichen Z, Naisheng Z*, Zhengtao Y*. Eur J Pharmacol. 2012 Aug 15;689(1-3):255-61.

其它作者顺序署名SCI论文:
[1] Effect of estrogen on prostaglandin synthetase in bovine oviduct smooth muscle.Huang N#, Wang C#, Zhang N, Mao W, Liu B, Shen Y, Gao Y, Zhao Y, Cao J*.Eur J Pharmacol. 2018 Jan 5;818:287-293.
[2] The prostaglandin E2 receptor PTGER2 and prostaglandin F2α receptor PTGFR mediate oviductal glycoprotein 1 expression in bovine oviductal epithelial cells.Zhang N, Mao W, Zhang Y, Huang N, Liu B, Gao L, Zhang S, Cao J*.J Reprod Dev. 2017 Dec 23. doi: 10.1262/jrd.2017-076. [Epub ahead of print]
[3]Kinetic effect of oestrogen on secretion of prostaglandins E2 and F2α in bovine oviduct epithelial cells.Dong Z#, Zhang N#, Mao W, Liu B, Huang N, Li P, Li C, Cao J*.ReprodFertil Dev. 2017 Mar;29(3):482-489.
[4] Classical swine fever virus replicated poorly in cells from MxA transgenic pigs.Zhao Y*, Wang T, Yao L, Liu B, Teng C, Ouyang H*.BMC Vet Res. 2016 Aug 17;12(1):169.
[5] Inhibiting cyprinid herpesvirus-3 replication with CRISPR/Cas9.Zhao Y, Wang T, Yu Z, Wang H, Liu B, Wu C, Teng CB*.Biotechnol Lett. 2016 Apr;38(4):573-8.
[6] Farrerol regulates antimicrobial peptide expression and reduces Staphylococcus aureus internalization into bovine mammary epithelial cells. Yang Z, Fu Y, Liu B, Zhou E, Liu Z, Song X, Li D, Zhang N*. MicrobPathog. 2013 Dec;65:1-6.
[7] Staphylococcusaureus and Escherichia coli elicit different innate immune responses from bovine mammary epithelial cells. Fu Y, Zhou E, Liu Z, Li F, Liang D, Liu B, Song X, Zhao F, Fen X, Li D, Cao Y, Zhang X, Zhang N, Yang Z*. Vet ImmunolImmunopathol. 2013 Oct 1;155(4):245-52.
[8] Emodin ameliorates lipopolysaccharide-induced mastitis in mice by inhibiting activation of NF-κB and MAPKs signal pathways. Li D, Zhang N, Cao Y, Zhang W, Su G, Sun Y, Liu Z, Li F, Liang D, Liu B, Guo M, Fu Y, Zhang X, Yang Z*. Eur J Pharmacol. 2013 Apr 5;705(1-3):79-85.
[9] Magnolol inhibits lipopolysaccharide-induced inflammatory response by interfering with TLR4 mediated NF-κB and MAPKs signaling pathways. Fu Y, Liu B, Zhang N, Liu Z, Liang D, Li F, Cao Y, Feng X, Zhang X*, Yang Z*. J Ethnopharmacol. 2013 Jan 9;145(1):193-9.
[10] Lipopolysaccharide increases Toll-like receptor 4 and downstream Toll-like receptor signaling molecules expression in bovine endometrial epithelial cells. Fu Y, Liu B, Feng X, Liu Z, Liang D, Li F, Li D, Cao Y, Feng S, Zhang X, Zhang N, Yang Z*. Vet ImmunolImmunopathol. 2013 Jan 15;151(1-2):20-7.
[11] Salidroside attenuates inflammatory responses by suppressing nuclear factor-κB and mitogen activated protein kinases activation in lipopolysaccharide-induced mastitis in mice. Li D, Fu Y, Zhang W, Su G, Liu B, Guo M, Li F, Liang D, Liu Z, Zhang X, Cao Y, Zhang N, Yang Z*. Inflamm Res. 2013 Jan;62(1):9-15.
[12] Stevioside suppressed inflammatory cytokine secretion by downregulation of NF-κB and MAPK signaling pathways in LPS-stimulated RAW264.7 cells. Fengyang L, Yunhe F, Bo L, Zhicheng L, Depeng L, Dejie L, Wen Z, Yongguo C, Naisheng Z, Xichen Z*, Zhengtao Y*. Inflammation. 2012 Oct;35(5):1669-75.

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