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刘博

添加时间:2019-12-17 15:44:41  浏览次数:[]

刘博,男,汉族,黑龙江省哈尔滨市人,19855月生,中共党员,副教授,硕士生导师,二级学科临床兽医学学科助理,内蒙古自治区高等学校青年科技英才支持计划入选者,主要研究方向为奶牛乳腺炎及子宫内膜炎诊断防治。

教育及工作经历

2008年毕业于东北林业大学野生动物资源学院动物医学专业,获得学士学位;

2013年硕博连读毕业于吉林大学动物医学学院临床兽医学专业,获得博士学位;

2013年通过高层次人才引进计划(第五层次A类)进入内蒙古农业大学兽医学院临床兽医学内科诊断教研室工作。

主持科研项目情况(国家级项目2项、自治区级项目3项、校级人才支持类项目3项)

[1] 国家自然科学基金地区科学基金项目,PGE2PGF对奶牛子宫内膜上皮细胞促增殖作用及其机制研究,项目号318607222019.01-2022.12,直接经费39万元,主持

[2] 国家自然科学基金地区科学基金项目,PGE2PGF对奶牛子宫内膜上皮细胞TLR2TLR4RP105参与的信号转导通路激活的调控,项目号315607142016.01-2019.12,直接经费41万,间接经费8.2万,经费总额49.2万元,主持

[3] 内蒙古自治区高等学校青年科技英才支持计划,项目号NJYT-18-B032018.01-2019.12,农业,20万元,主持(自治区级人才奖励项目)

[4] 内蒙古自治区人才开发基金,PGFPGE2对奶牛乳腺上皮细胞TLRs介导的天然免疫应答的调控作用,5万元,主持

[5] 内蒙古自治区自然科学基金项目,PGFPGE2在奶牛子宫内膜上皮细胞中对TLRs介导的天然免疫的调控,项目号2014BS03232014.01-2016.123万元,主持

[6] 内蒙古农业大学优秀青年科学基金培养项目,金黄色葡萄球菌脂蛋白在TLRsNLRP3炎性复合体介导的小鼠巨噬细胞激活中的作用研究,项目号2017XYQ-22018.01-2020.1229万元,主持

[7] 内蒙古农业大学优秀青年科学基金项目,PGFPGE2在奶牛乳腺上皮细胞TLRs介导的天然免疫中的调控作用,项目号2014XYQ-32014.10-2017.1015万元,主持

[8] 内蒙古农业大学引进人才科研启动基金,PGFPGE2对金葡菌在奶牛乳腺上皮细胞中的存活和细胞天然免疫应答的影响,项目号YJ2014-32015.01-2017.1210万元,主持

第一及通讯作者署名SCI论文发表情况(*通讯作者,#共同第一作者)

[1] Prostaglandin E2 Regulates Activation of Mouse Peritoneal Macrophages by Staphylococcus aureus through TLR2, TLR4, and NLRP3 Inflammasome Signaling. Jindi Wu, Bo Liu*, Wei Mao, Shuang Feng, Yuan Yao, Fan Bai, Yuan Shen, Amu Guleng, Bayin Jirigala, Jinshan Cao*. J Innate Immun. 2019 May 29:1-16. doi: 10.1159/000499604. [Epub ahead of print]

[2] Regulatory roles of PGE2 in LPS-induced tissue damage in bovine endometrial explants. Deng Y#, Liu B#, Mao W#, Shen Y, Fu C, Gao L, Zhang S, Wu J, Li Q, Li T, Liu K, Cao J*.Eur J Pharmacol. 2019 Mar 28;852:207-217.

[3] Prostaglandin E2 promotes Pam3CSK4-induced inflammation in endometrial epithelial cells of cattle. Yuan Shen#, Shuang Feng#, Bo Liu*,#, Wei Mao, Ruifeng Gao, Jindi Wu, Yang Deng, Long Gao, Shuangyi Zhang, Qianru Li, Jinshan Cao*. Anim Reprod Sci. Anim Reprod Sci. 2019 Jan;200:51-59.

[4] PGE2 downregulates LPS-induced inflammatory responses via the TLR4-NF-κB signaling pathway in bovine endometrial epithelial cells. Shen Y#, Liu B*,#, Mao W, Gao R, Feng S, Qian Y, Wu J, Zhang S, Gao L, Fu C, Li Q, Deng Y, Cao J*. Prostaglandins Leukot Essent Fatty Acids. 2018 Feb;129:25-31.

[5] Concentration effect of prostaglandin E2 on the growth factor expression and cell proliferation in bovine endometrial explants and their kinetic characteristics. Zhang S#, Mao W#, Li Q, Gao R, Zhang Y, Gao L, Fu C, Wu J, Deng Y, Shen Y, Li T, Liu B*, Cao J*. Reprod Domest Anim. 2018 Feb;53(1):143-151.

[6] PTGER2 activation induces PTGS-2 and growth factor gene expression in endometrial epithelial cells of cattle. Gao L#, Liu B#, Mao W, Gao R, Zhang S, Duritahala, Fu C, Shen Y, Zhang Y, Zhang N, Wu J, Deng Y, Wu X, Cao J*. Anim Reprod Sci. 2017 Dec;187:54-63.

[7] Prostaglandin F-PTGFR signalling activation, growth factor expression and cell proliferation in bovine endometrial explants. Zhang S#, Liu B#, Gao L, Mao W, Fu C, Duritahala D, Zhang N, Zhang Y, Shen Y, Cao J*. Reprod Fertil Dev. 2017 Oct;29(11):2195-2205.

[8] The effect of prostaglandin E2 receptor (PTGER2) activation on growth factor expression and cell proliferation in bovine endometrial explants. Zhang S#, Liu B#, Mao W, Li Q, Fu C, Zhang N, Zhang Y, Gao L, Shen Y, Cao J*.Prostaglandins Leukot Essent Fatty Acids. 2017 Jul;122:16-23.

[9] Prostanoid receptors EP2, EP4, and FP are regulated by estradiol in bovine oviductal smooth muscle. Huang N#, Liu B#, Dong Z, Mao W, Zhang N, Li C, Cao J*.Prostaglandins Other Lipid Mediat. 2015 Sep;121(Pt B):170-5.

[10] Involvement of RP105 and Toll-like receptors in the activation of mouse peritoneal macrophages by Staphylococcus aureus. Bo Liu, Yunhe Fu, Shuang Feng, Xichen Zhang, Zhicheng Liu, Yongguo Cao, Depeng Li, Dejie Liang, Fengyang Li, Naisheng Zhang, Zhengtao Yang*. Scand J Immunol. 2013 Jul;78(1):8-16.

[11] RP105 involved in activation of mouse macrophages via TLR2 and TLR4 signaling. Bo Liu, Naisheng Zhang, Zhicheng Liu, Yunhe Fu, Shuang Feng, Shan Wang, Yongguo Cao, Depeng Li, Dejie Liang, Fengyang Li, Xiaojing Song, Zhengtao Yang*. Molecular and Cellular Biochemistry. 2013 Jun; 378(1-2):183-93.

[12] Geniposide, from Gardenia jasminoides Ellis, inhibits the inflammatory response in the primary mouse macrophages and mouse models. Fu Y#, Liu B#, Liu J, Liu Z, Liang D, Li F, Li D, Cao Y, Zhang X, Zhang N*, Yang Z*. IntImmunopharmacol. 2012 Dec;14(4):792-8.

[13] The effect of magnolol on the Toll-like receptor 4/nuclear factor kappa B signaling pathway in lipopolysaccharide-induced acute lung injury in mice. Yunhe F#, Bo L#, Xiaosheng F, Fengyang L, Dejie L, Zhicheng L, Depeng L, Yongguo C, Xichen Z, Naisheng Z*, Zhengtao Y*. Eur J Pharmacol. 2012 Aug 15;689(1-3):255-61.

 

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