张双翼，男，汉族，内蒙古赤峰市人，1989年4月生，中共党员，内蒙古农业大学海外引进人才，特聘副教授，硕士生导师。内蒙古自治区“留学人员创新创业启动支持项目”获得者，教育部、农业农村部、中国科协三部委全国科技小院常驻专家，中国兽医协会牛羊兽医分会会员，内蒙古兽医学会理事，内蒙古生物工程学会理事，国家自然科学基金委员会生命科学部农业动物科学处兽医学科项目函评专家，Cell communication and signaling、Frontiers in Veterinary Science和International Immunopharmacology等SCI期刊审稿专家，主要研究方向为草食家畜普通病防治。

一、教育及工作经历

2013年毕业于沈阳农业大学畜牧兽医学院动物医学专业，获得学士学位；

2016年毕业于内蒙古农业大学兽医学院基础兽医学专业，获得硕士学位；

2021年毕业于日本酪农学园大学大学院兽医学专业，获得博士学位

2021年通过高层次人才引进计划进入内蒙古农业大学兽医学院动物生理学与药理学教研室工作。

二、主持科研项目和人才奖励项目情况（国家级1项、省部级3项，校级1项）

[1] 国家自然科学青年科学基金项目（C类）[原青年科学基金项目]，NLRP3和PGE2对奶牛巨噬细胞和肌成纤维细胞相互作用的调控机制研究，项目号32202879，2023.01-2025.12，30万元，主持；

[2] 内蒙古自治区高等学校科学研究重点项目，NLRP3对奶牛巨噬细胞和肌成纤维细胞相互作用的影响，项目号NJZZ23035，2023.01-2025.12，6万元，主持；

[3] 内蒙古自然科学基金面上项目，MLKL对小鼠巨噬细胞和成纤维细胞相互作用的调控机制研究，项目号2024MS03064，2024.01-2026.12，10万元，主持；

[4] 内蒙古自治区留学人员创新创业启动支持项目，2023.09-2026.08，3万元，主持（自治区级人才奖励项目）；

[5] 内蒙古农业大学人才引进科研启动项目，2022.08-2025.07，10万元，主持

三、第一作者和通讯作者署名论文发表情况（*通讯作者，#共同第一作者）

SCI论文：

[1] Prostaglandin F2α-PTGFR signalling activation, growth factor expression and cell proliferation in bovine endometrial explants. Zhang S#, Liu B#, Gao L, Mao W, Fu C, Duritahala D, Zhang N, Zhang Y, Shen Y, Cao J*. Reprod Fertil Dev. 2017 Oct;29(11):2195-2205.

[2] The effect of prostaglandin E2 receptor (PTGER2) activation on growth factor expression and cell proliferation in bovine endometrial explants. Zhang S#, Liu B#, Mao W, Li Q, Fu C, Zhang N, Zhang Y, Gao L, Shen Y, Cao J. Prostaglandins Leukot Essent Fatty Acids. 2017 Jul;122:16-23.

[3] Concentration effect of prostaglandin E2 on the growth factor expression and cell proliferation in bovine endometrial explants and their kinetic characteristics. S Zhang#, W Mao#, Q Li, R Gao, Y Zhang, L Gao, C Fu, J Wu, Y Deng, Y Shen, T Li, B Liu*, J Cao*. Reprod Dom Anim. 2018; 53: 143–151.

[4] Αlpha1B-adrenoceptor-mediated positive inotropic and positive chronotropic actions in the mouse atrium. Zhang S, Takahashi R, Yamashita N, Teraoka H, Kitazawa T*. Eur J Pharmacol. 2018 Nov 15;839:82-88.

[5] Identification of pheasant ghrelin and motilin and their actions on contractility of the isolated gastrointestinal tract. Zhang S, Okuhara Y, Iijima M, Takemi S, Sakata I, Kaiya H, Teraoka H, Kitazawa T*. Gen Comp Endocrinol. 2020 Jan 1;285:113294.

[6] 17β-estradiol regulates prostaglandin E2 and F2α synthesis and function in endometrial explants of cattle. Li Q#, Zhang S#, Mao W, Fu C, Shen Y, Wang Y, Liu B*, Cao J*. Anim Reprod Sci. 2020 May;216:106466.

[7] Motilin- and ghrelin-induced contractions in isolated gastrointestinal strips from three species of frogs. Zhang S, Teraoka H, Kaiya H, Kitazawa T*. Gen Comp Endocrinol. 2021 Jan 1;300:113649.

[8] Pheasant motilin, its distribution and gastrointestinal contractility-stimulating action in the pheasant. Zhang S, Kaiya H, Teraoka H, Kitazawa T*. Gen Comp Endocrinol. 2021 Dec 1;314:113897.

[9] Prostaglandin E receptor 2 mediates the inducible effects of prostaglandin E2 on expression of growth factors and enzymes in cattle endometrial epithelial cells and explants. Zhang S, Li Q, Mao W, Zhao J, Gong Z, Liu B*, Cao J*. Anim Sci J. 2022 Jan-Dec;93(1):e13766.

[10] Codonopsis pilosula polysaccharides attenuate Escherichia coli-induced acute lung injury in mice. Gong Z#, Zhang S#, Gu B#, Cao J, Mao W, Yao Y, Zhao J, Ren P, Zhang K, Liu B*. Food Funct. 2022 Aug 1;13(15):7999-8011.

[11] Motilin is a regulator of gastric contraction in Japanese fire belly newts (Cynops pyrrhogaster), in vitro studies using isolated gastrointestinal strips of newts, rabbits, and chickens. Zhang S, Kaiya H, Kitazawa T*. Gen Comp Endocrinol. 2023 Jan 1;330:114140.

[12] Braun Lipoprotein Protects against Escherichia coli-Induced Inflammatory Responses and Lethality in Mice. Shen Y#, Gong Z#, Zhang S#, Cao J, Mao W, Fu Y, Su N, Ding Y, Zhao J, Gu B, Feng S*, Liu B*. Microbiol Spectr. 2023 Mar 14;11(2):e0354122.

[13] Besides TLR2 and TLR4, NLRP3 is also involved in regulating Escherichia coli infection-induced inflammatory responses in mice. Shen Y#, Gong Z#, Zhang S#, Cao J, Mao W, Yao Y, Zhao J, Li Q, Liu K, Liu B*, Feng S*. Int Immunopharmacol. 2023 Aug;121:110556.

[14] Does ghrelin regulate intestinal motility in rabbits? An in vitro study using isolated duodenal strips. Zhang S, Kaiya H, Kitazawa T*. Gen Comp Endocrinol. 2023 Dec 1;344:114384.

[15] The roles of Braun Lipoprotein in inducing tolerance of bovine endometrium infected by Escherichia coli. Gong Z#, Ren P#, Bao H#, Mao W, Zhao J, Yu Z, Shen Y, Liu Y, Liu B*, Zhang S*. Anim Reprod Sci. 2024 Jul;266:107513.

[16] Taurochenodeoxycholic acid ameliorates the Staphylococcus aureus infection-induced acute lung injury through toll-like receptor 2 in mice. Gong Z, Mao W, Ren P, Hao Z, Zhao J, Yu Z, Zhao Y, Feng Y, Liu B*, Zhang S*. Int Immunopharmacol. 2024 Dec 5;142(Pt B):113228.

[17] Matrine alleviates Staphylococcus aureus-induced acute lung injury in mice by inhibiting MLKL and NLRP3-mediated inflammatory activity. Zhao J#, Gong Z#, Bao W, Liu X, Yu Z, Dong YQ, Mao W, Liu B*, Zhang S*. Eur J Pharmacol. 2025 Apr 15;993:177385.

[18] NLRP3: a key regulator of skin wound healing and macrophage-fibroblast interactions in mice. Zhao J#, Zhang S#,*, Gong Z, Mao W, Bao W, Li Q, Bai Y, Gao F, Feng S*. Cell Commun Signal. 2025 Jan 29;23(1):55.

[19] Physiological roles of ghrelin in the regulation of gastrointestinal motility in vertebrates. Zhang S, Kaiya H, Kitazawa T*. Gen Comp Endocrinol. 2025 Apr;365:114698.

核心期刊论文：

[1]冯爽,赵佳敏,巩志国,刘博* & 张双翼*.(2023).PTGER2激活对奶牛子宫内膜组织中生长因子表达的影响.中国兽医学报,43(07),1491-1496+1505.

[2] 包文慧, 赵佳敏, 巩志国, 白云洁, 于琢雅, 刘博, 毛伟, 张双翼*. MLKL在小鼠皮肤伤口愈合过程中的作用[J]. 中国农业大学学报, 2024, 29 (10): 230-238.

[3] 刘博, 巩志国, 赵佳敏, 于琢雅, 刘谕泽, 白云洁, 王超, 秦少杰, 吴敬泽, 包文慧, 张双翼*. MLKL对金黄色葡萄球菌感染所致小鼠肝脏和肾脏损伤的调控作用[J]. 中国兽医学报, 2024, 44 (04): 670-676.

[4] 王奕心, 巩志国, 代佳山, 董妍沁, 赵非凡, 任佩佩, 赵佳敏, 秦少杰, 张双翼*, 刘博*. 普雷沃氏菌对肠道菌群失调所致小鼠子宫组织损伤的保护作用[J]. 微生物学通报(网络首发)

四、专利

[1] 赵一, 曹金山, 毛伟, 白玉廷, 张双翼, 刘博, 杨金丽, 韩润林, 哈斯苏荣, 李培锋, 王馨悦, 郭莉莉. 一种卵黄低密度脂蛋白和头孢噻呋的融合方法及其应用: 内蒙古自治区, CN116970069A[P]. 2023-10-31

[2] 毛伟, 王永菲, 曹金山, 刘博, 白玉廷, 张双翼, 赵一, 李培锋, 哈斯苏荣, 巩志国, 赵佳敏. 一种卡那霉素鹅去氧胆酸偶联物及其制备方法与应用: 内蒙古自治区, CN118852309A[P]. 2024-10-29

[3] 何秀玲, 郭文瑞, 屈刚刚, 毛伟, 刘博, 曹金山, 李培锋, 李浩波, 张双翼. 一种胆酸微囊制备用干燥装置及工艺: 内蒙古自治区, CN118582908B[P]. 2024-09-27

[4] 刘博, 杨效林, 毛伟, 张双翼, 曹金山, 王钰, 郭莉莉, 龚鹏飞, 赵佳敏, 巩志国. 奶牛骨髓源单核巨噬细胞诱导培养方法及应用: 内蒙古自治区, CN117384842A[P]. 2024-01-12