巩志国，男，汉族，1995年6月生，内蒙古锡林浩特市人，中共党员，特聘副教授。2025年作为第一层次优秀博士人才引进至内蒙古农业大学，同年入选自治区“英才兴蒙”工程第六类人才。担任Cell Communication and Signaling、Probiotics and Antimicrobial Proteins、Archives of Microbiology和Journal of Innate Immunity等SCI期刊审稿人，《中国猪业》青年编委。主要从事家畜泌乳及生殖系统疾病的发病机制与防治研究。

一、教育及工作经历

2019年毕业于内蒙古农业大学兽医学院动物医学专业，获学士学位；

2022年毕业于内蒙古农业大学兽医学院临床兽医学专业，获硕士学位，导师：刘博教授；

2025年毕业于内蒙古农业大学兽医学院临床兽医学专业，获博士学位，导师：刘博教授。

同年通过内蒙古农业大学优秀博士人才引进计划（第一层次）进入内蒙古农业大学兽医学院临床兽医教研室工作。

二、主持科研项目和人才奖励项目情况（国家级3项、自治区级7项、校级3项）

[1] 内蒙古农业大学人才引进科研启动项目，20万元，主持；

[2] 国家自然科学基金项目，布劳恩脂蛋白对大肠杆菌诱导的奶牛子宫内膜炎症反应的调控机制研究，项目号32160854，2022.01-2025.12，35万元，参与；

[3] 国家自然科学基金项目，PGE₂对金黄色葡萄球菌通过TLR2、TLR4和NLRP3诱导的奶牛骨髓源巨噬细胞天然免疫应答的调控机制研究，项目号32260903，2023.01-2026.12，33万元，参与。

[4] 内蒙古自治区直属高校基本科研业务费项目，基于肠道菌群挖掘大肠杆菌所致小鼠子宫内膜炎的调控机制，项目号BR231510，2023.01-2025.12，20万元，参与；

[5] 中央引导地方科技发展资金项目，肠道菌群对大肠杆菌所致小鼠子宫内膜炎的调控机制研究，项目号2022ZY0200，2022.09-2025.08，10万元，参与；

三、第一作者署名论文发表情况（^*通讯作者，^#共同第一作者）

SCI论文：

[1] Codonopsis pilosula polysaccharides attenuate Escherichia coli-induced acute lung injury in mice. Gong Z^#, Zhang S^#, Gu B^#, Cao J, Mao W, Yao Y, Zhao J, Ren P, Zhang K, Liu B^*. Food Funct. 2022 Aug 1;13(15):7999-8011.

[2] TLR2, TLR4, and NLRP3 mediated the balance between host immune-driven resistance and tolerance in Staphylococcus aureus-infected mice. Gong Z, Zhang J, Zhang S, Cao J, Fu Y, Hu X, Zhao J, Gu B, Li Q, Zhang K, Ren P, Liu B^*, Mao W^*. Microb Pathog. 2022 Aug;169:105671.

[3] Braun Lipoprotein Protects against Escherichia coli-Induced Inflammatory Responses and Lethality in Mice. Shen Y^#, Gong Z^#, Zhang S^#, Cao J, Mao W, Fu Y, Su N, Ding Y, Zhao J, Gu B, Feng S^*, Liu B^*. Microbiol Spectr. 2023 Mar 14;11(2):e0354122.

[4] Besides TLR2 and TLR4, NLRP3 is also involved in regulating Escherichia coli infection-induced inflammatory responses in mice. Shen Y^#, Gong Z^#, Zhang S^#, Cao J, Mao W, Yao Y, Zhao J, Li Q, Liu K, Liu B^*, Feng S^*. Int Immunopharmacol. 2023 Aug;121:110556.

[5] Prostaglandin D₂ regulates Escherichia coli-induced inflammatory responses through TLR2, TLR4, and NLRP3 in macrophages. Gong Z^#, Mao W^#, Jin F^#, Zhang S, Zhao J, Ren P, Yu Z, Bai Y, Wang C, Cao J^*, Liu B^*. Prostaglandins Other Lipid Mediat. 2023 Sep 3;169:106772.

[6] The roles of Braun Lipoprotein in inducing tolerance of bovine endometrium infected by Escherichia coli. Gong Z^#, Ren P^#, Bao H^#, Mao W, Zhao J, Yu Z, Shen Y, Liu Y, Liu B^*, Zhang S^*. Anim Reprod Sci. 2024 Jul;266:107513.

[7] Taurochenodeoxycholic acid ameliorates the Staphylococcus aureus infection-induced acute lung injury through toll-like receptor 2 in mice. Gong Z, Mao W, Ren P, Hao Z, Zhao J, Yu Z, Zhao Y, Feng Y, Liu B*, Zhang S*. Int Immunopharmacol. 2024 Dec 5;142(Pt B):113228.

[8] TLR2 and NLRP3 Orchestrate Regulatory Roles in Escherichia coli Infection-Induced Septicemia in Mouse Models. Gong Z, Mao W, Zhao J, Ren P, Yu Z, Bai Y, Wang C, Liu Y, Feng S^*, Hasi S^*. J Innate Immun. 2024;16(1):513-528.

[9] Matrine alleviates Staphylococcus aureus-induced acute lung injury in mice by inhibiting MLKL and NLRP3-mediated inflammatory activity. Zhao J^#, Gong Z^#, Bao W, Liu X, Yu Z, Dong YQ, Mao W, Liu B^*, Zhang S^*. Eur J Pharmacol. 2025 Feb 14;993:177385.

[10] Chebulagic acid inhibits lipopolysaccharide-induced endometritis by regulating mitogen-activated protein kinase/nuclear factor-κB signaling. Liu X^#, Gong Z^#, Yang Y^#, Dong J, Zhang L, Li Z, Zhao F, Zhang J^*, Gao R^*. J Reprod Immunol. 2025 Jun;169:104464.

[11] Comprehensive insights into oil absorption in fried foods: The role of surface characteristics. Zhang S^#, Gong Z^#, Wang S, Zhao S, Mao W, Liu B^*, Liu Y^*. Food Chem. 2025 Aug 15;483:144341.

[12]. An underlying mechanism of bovine mastitis: PGE₂ regulates Staphylococcus aureus-induced inflammatory response through TLR2, TLR4, and NLRP3 in macrophages. Gong Z^#, Yu Z^#, Ren P, Zhang S, Gao R, Zhao J, Wang Y, Qin S, Bao W, Shuang F^*. Vet Q. 2026 Jan;46(1):2615759.

核心期刊论文：

[1] 巩志国,顾柏臣,沈媛,李茜如,金凤,赵佳敏,刘博^*.布劳恩脂蛋白对大肠埃希氏菌感染导致的小鼠体内细胞因子分泌及死亡的调节作用[J].动物医学进展,2022,43(02):25-29.

[2] 李成应^#,巩志国^#,张双翼,刘博^*,毛伟^*.在LPS诱导的天然免疫反应中前列腺素D₂与TLR2和TLR4的相互调控作用[J].中国兽医学报,2023,43(06):1277-1283.

[3] 巩志国,赵佳敏,顾柏臣,任佩佩,于琢雅,白云洁,刘鑫煜,王超,刘博^*.基于网络药理学分析党参减轻大肠杆菌感染小鼠急性肺损伤的作用机制[J].畜牧兽医学报,2023,54(08):3571-3581.

[4] 刘博^#, 巩志国^#, 赵佳敏, 于琢雅, 刘谕泽, 白云洁, 王超, 秦少杰, 吴敬泽, 包文慧, 张双翼^*. MLKL对金黄色葡萄球菌感染所致小鼠肝脏和肾脏损伤的调控作用[J]. 中国兽医学报, 2024, 44 (04): 670-676.